Endocrine Abstracts

Increasing evidences indicate that brown adipose tissue (BAT) functional activity is reduced during obesity. The nature of this deficit in BAT function, however, is still poorly understood. To analyze whether insulin function in the BAT is altered during obesity, we studied the in vivo metabolic activity of BAT by PET/CT imaging and euglycaemic hyperinsulinemic clamp in lean and diet-induced obese mice. Three groups of mice were analyzed after administration of different diet ...

APECED is an autosomal – recessive syndrome defined by two of the following conditions: chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (HP) or Addison disease (AD). Other autoimmune endocrine or non-endocrine conditions may be associated, like thyroiditis, celiac disease, alopecia and nail dystrophy. APECED is caused by mutations in the AIRE gene, mapping to 21q22.3. We report here 4 cases with atypical or incomplete presentation, that have been geneti...